SME
Organic Chemistry II · Problem type
The product of an acyl substitution
Use this for “What forms when propanoyl chloride reacts with methylamine?”
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What does each reaction make?
Tap a card, then tap its group.
The nucleophile replaces the leaving group: look at the atom it bonds with.
Assumptions
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The nucleophile adds to the C=O carbon and the leaving group goes, so the nucleophile takes its place.
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An alcohol gives an ester, ammonia or an amine an amide, water an acid, and a carboxylate an anhydride.
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A second equivalent of amine, or pyridine, takes up the HCl a chloride gives off.
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Esters and amides need acid or base and heat; base gives the carboxylate, and H₃O⁺ then gives the acid.
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