SME
Tissue Engineering · Problem type
How a cell attaches to a material
Use this for “Put these in order on a new scaffold: the cell spreads, proteins adsorb, integrins bind RGD, focal adhesions form.”
Put in order
Put the events of a cell attaching to a material in order.
1
?
2
?
3
?
4
?
5
?
Assumptions
•
Cells never touch the bare material: they meet the protein layer that coats it first.
•
Integrins bind short peptide sites such as RGD in proteins like fibronectin and vitronectin.
•
The times are rough and overlap, to show the scale from minutes to days.
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